The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.

• Spider-Man / Peter Parker: Tobey Maguire
• Mary Jane Watson: Kirsten Dunst
• New Goblin / Harry Osborn: James Franco
• Sandman / Flint Marko: Thomas Haden Church
• Venom / Eddie Brock: Topher Grace
• Gwen Stacy: Bryce Dallas Howard
• May Parker: Rosemary Harris
• J. Jonah Jameson: J.K. Simmons
• Captain Stacey: James Cromwell
• Dr. Curt Connors: Dylan Baker
• Emma Marko: Theresa Russell
• Joseph ‘Robbie’ Robertson: Bill Nunn
• Maître D’: Bruce Campbell
• Miss Brant: Elizabeth Banks
• Hoffman: Ted Raimi
• Penny Marko: Perla Haney-Jardine
• Green Goblin / Norman Osborn: Willem Dafoe
• Ben Parker: Cliff Robertson
• Mr. Ditkovitch: Elya Baskin
• Ursula: Mageina Tovah
• Houseman: John Paxton
• Mrs. Stacy: Becky Ann Baker
• Man in Times Square: Stan Lee
• Dennis Carradine / Carjacker: Michael Papajohn
• Flash Thompson: Joe Manganiello
• Anchorman: Hal Fishman
• Jennifer Dugan: Lucy Gordon
• Photographer: Steve Valentine
• Play Director: Tim Maculan
• Play Producer: Marc Vann
• Jazz Club Manager: Joe Bays
• Precinct Detective: Gregg Daniel
• Emergency Room Doctor: Rogelio T. Ramos
• Crane Operator: Timothy Patrick Quill
• Kid in Times Square: Menachem Mendel Boymelgreen
• Kid in Times Square: Nasir Stewart
• Kid in Times Square: Austin Hendrickson
• Kid in Times Square: Taylor Hemhauser
• Woman Outside Theater: Kathryn Bryding
• Police Detective: Joe Virzi
• New Jersey State Policeman: Bill E. Rogers
• New Jersey State Policeman: Michael Alexander
• Test Site Technician: April Parker-Jones
• Test Site Technician: Edward Padilla
• Test Site Technician: Robert Curtis Brown
• Test Site Technician: Paul Terrell Clayton
• Test Site Technician: Carolyn Neff
• Test Site Technician: Christina Cindrich
• ICU Nurse: Sonya Maddox
• Crane Disaster Radio Policeman: Andre B. Blake
• Cop at Crane Disaster: Derrick ‘Phoenix’ Thomas
• Mary Jane’s Replacement: Jessi Collins
• Boy at Key to the City Ceremony: Michael McLaughlin
• Councilwoman: Anne Gartlan
• Policeman at Sand Truck: Emilio Rivera
• Policeman at Sand Truck: Keith Woulard
• Armored Car Driver: Reynaldo Gallegos
• Newstand Patron: Jim Coope
• Newsstand Patron: Dean Edwards
• Newsstand Patron: Margaret Laney
• Congratulatory Woman at Daily Bugle: Toni Wynne
• Coffee Shop Waitress: Aimee Miles
• Jazz Club Waitress: Tanya Bond
• Jazz Club Bouncer: Mark Kubr
• Girl With Camera: Emma Raimi
• Boy at the Final Battle: Lorne Raimi
• Boy at the Final Battle: Henry Raimi
• Girl at the Final Battle: Samantha Ressler
• Jazz Club Musician: Alan Cohn
• Jazz Club Musician: Dan Callahan
• Jazz Club Musician: Daniel Cummings
• Jazz Club Musician: Ron King
• Jazz Club Musician: Carol Chaikin
• Jazz Club Musician: Vance Hammond
• NYPD Officer (uncredited): Frank Anello
• Model (uncredited): Anya Avaeva
• Bucket Boy (uncredited): David Backus
• Photoshoot Client (uncredited): Tony Besson
• Photographer (uncredited): Michael Ciesla
• Jazz Club Waitress (uncredited): Irina Costa
• Theater Patron (uncredited): John Crann
• Jazz Club Girl (uncredited): Crystal Marie Denha
• Columbia Grad Student (uncredited): Amy V. Dewhurst
• New York City Commuter / Driver (uncredited): Paul Edney
• Girl at Key Ceremony (uncredited): Natalie Fabry
• Pedestrian (uncredited): Keith Fausnaught
• Automobile Driver (uncredited): Logan Fry
• Spectator (uncredited): Kevin Fung
• News Spectator (uncredited): Tony Galtieri
• News Reporter (uncredited): Brian Hopson
• Jazz Club Bouncer (uncredited): Andrew James Jones
• Girl at Key Ceremony (uncredited): Natalie Jones
• Student (uncredited): Christopher Jude
• ER Nurse (uncredited): Brittany Krall
• Woman in Court (uncredited): Pierangeli Llinas
• British Publicist (uncredited): Bernadette Lords
• Girl Screaming in Camaro (uncredited): Natalie McNeil
• Oscorp Receptionist (uncredited): Martha Millan
• Girl in Times Square (uncredited): Michele-Nanette Miller
• Robbie’s Assistant (uncredited): Claudia Katz Minnick
• Beautiful Girl (uncredited): Jen Oda
• Beautiful Woman (uncredited): Anjelia Pelay
• Police Officer (uncredited): Nick Poltoranin
• Beautiful Woman (uncredited): Vanessa Reseland
• Beautiful Woman (uncredited): La Rivers
• Businesswoman (uncredited): Bria Roberts
• Sandman Victim (uncredited): Vanessa Ross
• Bad Girl (uncredited): Brenna Roth
• City Hall Cheerer (uncredited): Shade Rupe
• Jazz Club Beatnik (uncredited): Eric Shackelford
• Jazz Club Guest (uncredited): Daniel Shafer
• Café Girl (uncredited): Abbey Skinner
• Jazz Club Patron (uncredited): Kristin Somo
• Jazz Club Waitress (uncredited): Jennifer Sparks
• Firefighter (uncredited): Christopher Stadulis
• Broadway Audience Member (uncredited): Arne Starr
• Model (uncredited): Aija Terauda
• Beautiful Woman (uncredited): Evelyn Vaccaro
• Bar Patron #5 (uncredited): Nick Vlassopoulos
• Model (uncredited): Sincerely A. Ward
• ER Nurse (uncredited): Jennifer Weston
• Spectator (uncredited): Ray Wineteer
• Beautiful Woman (uncredited): Emily Eckes

,

• Casting: Francine Maisler
• Executive Producer: Joseph M. Caracciolo Jr.
• Visual Effects: John Frazier
• Story: Sam Raimi
• Comic Book: Stan Lee
• Comic Book: Steve Ditko
• Editor: Bob Murawski
• Producer: Laura Ziskin
• Producer: Avi Arad
• Production Design: Neil Spisak
• Costume Design: James Acheson
• Screenplay: Alvin Sargent
• Executive Producer: Kevin Feige
• Director of Photography: Bill Pope
• Producer: Grant Curtis
• Story: Ivan Raimi
• Original Music Composer: Christopher Young
• Casting: Kathy Driscoll
• Production Design: J. Michael Riva
• Set Decoration: Leslie A. Pope
• Costume Design: Katina Le Kerr
• Sound Effects Editor: Richard C. Franklin
• Stunts: Hank Amos
• Unit Production Manager: Denis L. Stewart
• Art Direction: Christopher Burian-Mohr
• Art Direction: David F. Klassen
• Production Manager: Richard Baratta
• Art Direction: Dawn Swiderski
• Sound Effects Editor: Jussi Tegelman
• Sound Effects Editor: Chris M. Jacobson
• Stunt Double: Brad Martin
• Stunts: Natascha Hopkins
• Art Direction: Suzan Wexler
• Stunts: Aaron Vexler
• Makeup & Hair: Vivian Baker
• Still Photographer: Merrick Morton
• Casting Assistant: Katie Taylor
• Stunts: Samantha MacIvor
• Production Coordinator: Noelle Green
• Set Designer: Kevin Cross
• Script Supervisor: Trudy Ramirez
• Set Designer: Aric Cheng
• Set Designer: Noelle King
• Still Photographer: Merie Weismiller Wallace
• Set Designer: Barbara Mesney
• Set Designer: Jeff Markwith
• Visual Effects: Ian Hunter
• Sound Effects Editor: Bernard Weiser
• Set Designer: Andrea Dopaso
• Production Coordinator: V.W. Scheich
• Sound Effects Editor: Paul N.J. Ottosson
• Set Designer: Theodore Sharps
• Set Designer: Patte Strong-Lord
• Sound Effects Editor: Daniel Pagan
• Visual Effects Producer: Josh R. Jaggars
• Visual Effects Supervisor: Sheena Duggal
• Visual Effects: Scott Stokdyk
• Makeup & Hair: Jay Wejebe
• Makeup & Hair: Tina Earnshaw
• Makeup & Hair: Craig Lindberg
• Sound Effects Editor: Greg ten Bosch
• Visual Effects Editor: Earl A. Hibbert
• Production Supervisor: David J. Grant
• Production Coordinator: John DeSimone
• Stunts: Shawnna Thibodeau
• Stunts: Caroline Vexler
• Visual Effects Supervisor: PeiPei Alena Yuan
• Set Designer: Brett Phillips
• Location Manager: Andrew Saxe
• Location Manager: John Fedynich
• Casting Assistant: Will F. Moore
• Casting Assistant: Lavelle Brown
• Visual Effects: Spencer Cook
• Casting Assistant: Merry Alderman
• Casting Assistant: Neal Naito
• Casting Associate: Jeffrey Gafner
• Location Scout: Ellen Gessert
• Title Designer: Heebok Lee
• Production Coordinator: Greg Outcalt
• Stunts: Chrissy Weathersby Ball
• Visual Effects: Peter Nofz
• Storyboard Designer: Rick Newsome
• Additional Production Assistant: Patrick Tendai Pfupajena
• Stunts: Kimberly Shannon Murphy
• Stunt Double: Jimena Ferrante
• Stunt Double: Alexis Teague
• Stunt Double: Alison Hyatt Simpson

Credits: TheMovieDb.