The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
- Spider-Man / Peter Parker: Tobey Maguire
- Mary Jane Watson: Kirsten Dunst
- New Goblin / Harry Osborn: James Franco
- Sandman / Flint Marko: Thomas Haden Church
- Venom / Eddie Brock: Topher Grace
- Gwen Stacy: Bryce Dallas Howard
- May Parker: Rosemary Harris
- J. Jonah Jameson: J.K. Simmons
- Captain Stacey: James Cromwell
- Dr. Curt Connors: Dylan Baker
- Emma Marko: Theresa Russell
- Joseph ‘Robbie’ Robertson: Bill Nunn
- Maître D’: Bruce Campbell
- Miss Brant: Elizabeth Banks
- Hoffman: Ted Raimi
- Penny Marko: Perla Haney-Jardine
- Green Goblin / Norman Osborn: Willem Dafoe
- Ben Parker: Cliff Robertson
- Mr. Ditkovitch: Elya Baskin
- Ursula: Mageina Tovah
- Houseman: John Paxton
- Mrs. Stacy: Becky Ann Baker
- Man in Times Square: Stan Lee
- Dennis Carradine / Carjacker: Michael Papajohn
- Flash Thompson: Joe Manganiello
- Anchorman: Hal Fishman
- Jennifer Dugan: Lucy Gordon
- Photographer: Steve Valentine
- Play Director: Tim Maculan
- Play Producer: Marc Vann
- Jazz Club Manager: Joe Bays
- Precinct Detective: Gregg Daniel
- Emergency Room Doctor: Rogelio T. Ramos
- Crane Operator: Timothy Patrick Quill
- Kid in Times Square: Menachem Mendel Boymelgreen
- Kid in Times Square: Nasir Stewart
- Kid in Times Square: Austin Hendrickson
- Kid in Times Square: Taylor Hemhauser
- Woman Outside Theater: Kathryn Bryding
- Police Detective: Joe Virzi
- New Jersey State Policeman: Bill E. Rogers
- New Jersey State Policeman: Michael Alexander
- Test Site Technician: April Parker-Jones
- Test Site Technician: Edward Padilla
- Test Site Technician: Robert Curtis Brown
- Test Site Technician: Paul Terrell Clayton
- Test Site Technician: Carolyn Neff
- Test Site Technician: Christina Cindrich
- ICU Nurse: Sonya Maddox
- Crane Disaster Radio Policeman: Andre B. Blake
- Cop at Crane Disaster: Derrick ‘Phoenix’ Thomas
- Mary Jane’s Replacement: Jessi Collins
- Boy at Key to the City Ceremony: Michael McLaughlin
- Councilwoman: Anne Gartlan
- Policeman at Sand Truck: Emilio Rivera
- Policeman at Sand Truck: Keith Woulard
- Armored Car Driver: Reynaldo Gallegos
- Newstand Patron: Jim Coope
- Newsstand Patron: Dean Edwards
- Newsstand Patron: Margaret Laney
- Congratulatory Woman at Daily Bugle: Toni Wynne
- Coffee Shop Waitress: Aimee Miles
- Jazz Club Waitress: Tanya Bond
- Jazz Club Bouncer: Mark Kubr
- Girl With Camera: Emma Raimi
- Boy at the Final Battle: Lorne Raimi
- Boy at the Final Battle: Henry Raimi
- Girl at the Final Battle: Samantha Ressler
- Jazz Club Musician: Alan Cohn
- Jazz Club Musician: Dan Callahan
- Jazz Club Musician: Daniel Cummings
- Jazz Club Musician: Ron King
- Jazz Club Musician: Carol Chaikin
- Jazz Club Musician: Vance Hammond
- NYPD Officer (uncredited): Frank Anello
- Model (uncredited): Anya Avaeva
- Bucket Boy (uncredited): David Backus
- Photoshoot Client (uncredited): Tony Besson
- Photographer (uncredited): Michael Ciesla
- Jazz Club Waitress (uncredited): Irina Costa
- Theater Patron (uncredited): John Crann
- Jazz Club Girl (uncredited): Crystal Marie Denha
- Columbia Grad Student (uncredited): Amy V. Dewhurst
- New York City Commuter / Driver (uncredited): Paul Edney
- Girl at Key Ceremony (uncredited): Natalie Fabry
- Pedestrian (uncredited): Keith Fausnaught
- Automobile Driver (uncredited): Logan Fry
- Spectator (uncredited): Kevin Fung
- News Spectator (uncredited): Tony Galtieri
- News Reporter (uncredited): Brian Hopson
- Jazz Club Bouncer (uncredited): Andrew James Jones
- Girl at Key Ceremony (uncredited): Natalie Jones
- Student (uncredited): Christopher Jude
- ER Nurse (uncredited): Brittany Krall
- Woman in Court (uncredited): Pierangeli Llinas
- British Publicist (uncredited): Bernadette Lords
- Girl Screaming in Camaro (uncredited): Natalie McNeil
- Oscorp Receptionist (uncredited): Martha Millan
- Girl in Times Square (uncredited): Michele-Nanette Miller
- Robbie’s Assistant (uncredited): Claudia Katz Minnick
- Beautiful Girl (uncredited): Jen Oda
- Beautiful Woman (uncredited): Anjelia Pelay
- Police Officer (uncredited): Nick Poltoranin
- Beautiful Woman (uncredited): Vanessa Reseland
- Beautiful Woman (uncredited): La Rivers
- Businesswoman (uncredited): Bria Roberts
- Sandman Victim (uncredited): Vanessa Ross
- Bad Girl (uncredited): Brenna Roth
- City Hall Cheerer (uncredited): Shade Rupe
- Jazz Club Beatnik (uncredited): Eric Shackelford
- Jazz Club Guest (uncredited): Daniel Shafer
- Café Girl (uncredited): Abbey Skinner
- Jazz Club Patron (uncredited): Kristin Somo
- Jazz Club Waitress (uncredited): Jennifer Sparks
- Firefighter (uncredited): Christopher Stadulis
- Broadway Audience Member (uncredited): Arne Starr
- Model (uncredited): Aija Terauda
- Beautiful Woman (uncredited): Evelyn Vaccaro
- Bar Patron #5 (uncredited): Nick Vlassopoulos
- Model (uncredited): Sincerely A. Ward
- ER Nurse (uncredited): Jennifer Weston
- Spectator (uncredited): Ray Wineteer
- Beautiful Woman (uncredited): Emily Eckes
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- Casting: Francine Maisler
- Executive Producer: Joseph M. Caracciolo Jr.
- Visual Effects: John Frazier
- Story: Sam Raimi
- Comic Book: Stan Lee
- Comic Book: Steve Ditko
- Editor: Bob Murawski
- Producer: Laura Ziskin
- Producer: Avi Arad
- Production Design: Neil Spisak
- Costume Design: James Acheson
- Screenplay: Alvin Sargent
- Executive Producer: Kevin Feige
- Director of Photography: Bill Pope
- Producer: Grant Curtis
- Story: Ivan Raimi
- Original Music Composer: Christopher Young
- Casting: Kathy Driscoll
- Production Design: J. Michael Riva
- Set Decoration: Leslie A. Pope
- Costume Design: Katina Le Kerr
- Sound Effects Editor: Richard C. Franklin
- Stunts: Hank Amos
- Unit Production Manager: Denis L. Stewart
- Art Direction: Christopher Burian-Mohr
- Art Direction: David F. Klassen
- Production Manager: Richard Baratta
- Art Direction: Dawn Swiderski
- Sound Effects Editor: Jussi Tegelman
- Sound Effects Editor: Chris M. Jacobson
- Stunt Double: Brad Martin
- Stunts: Natascha Hopkins
- Art Direction: Suzan Wexler
- Stunts: Aaron Vexler
- Makeup & Hair: Vivian Baker
- Still Photographer: Merrick Morton
- Casting Assistant: Katie Taylor
- Stunts: Samantha MacIvor
- Production Coordinator: Noelle Green
- Set Designer: Kevin Cross
- Script Supervisor: Trudy Ramirez
- Set Designer: Aric Cheng
- Set Designer: Noelle King
- Still Photographer: Merie Weismiller Wallace
- Set Designer: Barbara Mesney
- Set Designer: Jeff Markwith
- Visual Effects: Ian Hunter
- Sound Effects Editor: Bernard Weiser
- Set Designer: Andrea Dopaso
- Production Coordinator: V.W. Scheich
- Sound Effects Editor: Paul N.J. Ottosson
- Set Designer: Theodore Sharps
- Set Designer: Patte Strong-Lord
- Sound Effects Editor: Daniel Pagan
- Visual Effects Producer: Josh R. Jaggars
- Visual Effects Supervisor: Sheena Duggal
- Visual Effects: Scott Stokdyk
- Makeup & Hair: Jay Wejebe
- Makeup & Hair: Tina Earnshaw
- Makeup & Hair: Craig Lindberg
- Sound Effects Editor: Greg ten Bosch
- Visual Effects Editor: Earl A. Hibbert
- Production Supervisor: David J. Grant
- Production Coordinator: John DeSimone
- Stunts: Shawnna Thibodeau
- Stunts: Caroline Vexler
- Visual Effects Supervisor: PeiPei Alena Yuan
- Set Designer: Brett Phillips
- Location Manager: Andrew Saxe
- Location Manager: John Fedynich
- Casting Assistant: Will F. Moore
- Casting Assistant: Lavelle Brown
- Visual Effects: Spencer Cook
- Casting Assistant: Merry Alderman
- Casting Assistant: Neal Naito
- Casting Associate: Jeffrey Gafner
- Location Scout: Ellen Gessert
- Title Designer: Heebok Lee
- Production Coordinator: Greg Outcalt
- Stunts: Chrissy Weathersby Ball
- Visual Effects: Peter Nofz
- Storyboard Designer: Rick Newsome
- Additional Production Assistant: Patrick Tendai Pfupajena
- Stunts: Kimberly Shannon Murphy
- Stunt Double: Jimena Ferrante
- Stunt Double: Alexis Teague
- Stunt Double: Alison Hyatt Simpson
Credits: TheMovieDb.